Research Impact

This selection highlights publications from our customers' extensive research utilizing PETsys technology. Authored by leading researchers and institutions worldwide, their work spans medical imaging, innovative detector development, and high-energy physics, demonstrating how customers are advancing their fields with PETsys solutions.

While these publications highlight important academic contributions, they represent only one dimension of PETsys technology adoption. Many customers operate in commercial environments where proprietary development and competitive considerations preclude public disclosure. These commercially-driven partners are developing next-generation PET scanners and advanced imaging systems for clinical and industrial applications.

• Development of diode-based row–column multiplexing boards with the TOFPET2 ASIC for clinical TOF-PET systems
  H.G. Kang, E. Yoshida, G. Akamatsu, T. Yamaya,
  Physics in Medicine & Biology. 70 (2025) 225001

• Performance evaluation of a multiplexing circuit combined with ASIC readout for cost-effective brain PET imaging
  F. Pagano, F. Loignon-Houle, D. Sanchez, J. Barberá, J. Alamo, E. Elmoujarkach, N.A. Karakatsanis, S.A. Nehmeh, A.J. Gonzalez,
  Physics in Medicine & Biology. 70 (2025) 205001

• Dual-ended readout TOF-DOI PET detectors based on 3.2 mm and 1.6 mm pitch LYSO arrays.
  H. Wang, J. Xie, J. Qi, S.R. Cherry, J. Du,
  EJNMMI Phys. 2025;12(1):51

• Muon Tracking in a LiquidO Opaque Scintillator Detector
  Collaboration, LiquidO, et al.
  https://arxiv.org/abs/2507.13864

• Study of the TOFPET2c ASIC in time-of-flight detection of x-rays for scatter rejection in medical imaging applications
  L.-D. Gaulin, V. Nadig, K. Herweg, G. Lemaire, F. Gagnon, J. Bouchard, J. Rossignol, V. Schulz, R. Fontaine, S. Gundacker,
  Physics in Medicine & Biology. 70 (2025) 045011
  
  
• High-resolution motion compensation for brain PET imaging using real-time electromagnetic motion tracking
  W.Tan, Z. Wang, X. Zeng, A. Boccia, X. Wang, Y. Li, Y. Li,  E. K. Fung, J. Qi, T. Zeng, A. Gupta, A. H. Goldan
  Medical Physics. 52 (2025) 201–218

• A multi-resolution TOF-DOI detector for human brain dedicated PET scanner
  W. He, Y. Zhao, W. Huang, X. Zhao, M. Niu, H. Yang, L. Zhang, Q. Ren, Z. Gu,
  Physics in Medicine & Biology. 69 (2024) 025023

• Scalable, Time-of-Flight and Depth-of-Interaction Detector Units for High-Resolution PET Systems
  V. Nadig, S. Gundacker, D. Schug, K. Herweg, K. Weindel, H. Radermacher, F. Mueller, B. Weissler, V. Schulz,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 8 (2024) 1–14

• First Results of the 4D-PET Brain System
  A. Gonzalez-Montoro, S. Jiménez-Serrano, J. Álamo, J. Barberá, A. Lucero, N. Cucarella, K. Díaz, M. Freire, A.J. Gonzalez, L. Moliner, Á. Mondejar, C. Morera-Ballester, J. Prior, D. Sánchez, J.M. Benlloch,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 8 (2024) 839–849

• The first probe of a FLASH proton beam by PET
  F. Abouzahr, J.P. Cesar, P. Crespo, M. Gajda, Z. Hu, K. Klein, A.S. Kuo, S. Majewski, O. Mawlawi, A. Morozov, A. Ojha, F. Poenisch, M. Proga, N. Sahoo, J. Seco, T. Takaoka, S. Tavernier, U. Titt, X. Wang, X.R. Zhu, K. Lang,
  Physics in Medicine & Biology. 68 (2023) 235004

• A CNN-based four-layer DOI encoding detector using LYSO and BGO scintillators for small animal PET imaging
  W. He, Y. Zhao, X. Zhao, W. Huang, L. Zhang, D.L. Prout, A.F. Chatziioannou, Q. Ren, Z. Gu,
  Physics in Medicine & Biology. 68 (2023) 095021

• Development of a muon detector based on a plastic scintillator and WLS fibers to be used for muon tomography system
  C. Park, K.B. Kim, M.K. Baek, Soo In-Kang, S. Lee, Y.S. Chung, H. Chung, Y.H. Chung,
  Nuclear Engineering and Technology. 55 (2023) 1009–1014

• Preliminary evaluation of a compact, high sensitivity and high resolution small animal PET prototype
  W. He, Y. Zhao, X. Zhao, W. Huang, G. Li, Z. Zhang, H. Yang, M. Niu, D.L. Prout, A. Chatziioannou, Q. Ren, Z. Gu,
  in: 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD), 2023: pp. 1

• Timing advances of commercial divalent-ion co-doped LYSO:Ce and SiPMs in sub-100 ps time-of-flight positron emission tomography
  V. Nadig, K. Herweg, M.M.C. Chou, J.W.C. Lin, E. Chin, C.-A. Li, V. Schulz, S. Gundacker,
  Physics in Medicine & Biology. 68 (2023) 075002

• Time and Energy Characterization of Semi-Monolithic Detectors With Different Treatments and SiPMs Suitable for Clinical Imaging
  J. Barrio, N. Cucarella, M. Freire, C. Valladares, J.M. Benlloch, A.J. Gonzalez,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 7 (2023) 785–793

• On the Prospects of BaF2 as a Fast Scintillator for Time-of-Flight Positron Emission Tomography Systems
  K. Herweg, V. Nadig, V. Schulz, S. Gundacker,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 7 (2023) 241–252

• A conformal TOF–DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging
  X. Zeng, Z. Wang, W. Tan, E. Petersen, X. Cao, A. LaBella, A. Boccia, D. Franceschi, M. de Leon, G.C.-Y. Chiang, J. Qi, A. Biegon, W. Zhao, A.H. Goldan,
  Medical Physics. 50 (2023) 3401–3417

• A Comprehensive Study on the Timing Limits of the TOFPET2 ASIC and on Approaches for Improvements
  V. Nadig, M. Yusopova, H. Radermacher, D. Schug, B. Weissler, V. Schulz, S. Gundacker,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 6 (2022) 893–903

• Timing evaluation of a PET detector block based on semi-monolithic LYSO crystals
  N. Cucarella, J. Barrio, E. Lamprou, C. Valladares, J.M. Benlloch, A.J. Gonzalez,
  Medical Physics. 48 (2021) 8010–8023

• Feasibility Study of a Time-of-Flight Brain Positron Emission Tomography Employing Individual Channel Readout Electronics
  K. Park, J. Jung, Y. Choi, H. Leem, Y. Kim,
  Sensors. 21 (2021)

• Performance evaluation of a staggered three-layer DOI PET detector using a 1 mm LYSO pitch with PETsys TOFPET2 ASIC: comparison of HAMAMATSU and KETEK SiPMs
  T. Binder, H.G. Kang, M. Nitta, F. Schneider, T. Yamaya, K. Parodi, F. Wiest, P.G. Thirolf,
  Physics in Medicine & Biology. 66 (2021) 125016

• Evaluation of the PETsys TOFPET2 ASIC In Multi-Channel Coincidence Experiments
  V. Nadig, D. Schug, B. Weissler, V. Schulz,
  EJNMMI Physics. 8 (2021) 30

• A thick semi-monolithic scintillator detector for clinical PET scanners
  C. Zhang, X. Wang, M. Sun, Z. Kuang, X. Zhang, N. Ren, S. Wu, Z. Sang, T. Sun, Z. Hu, Y. Yang, Z. Liu,
  Physics in Medicine & Biology. 66 (2021) 065023

• First imaging demonstration of a crosshair light-sharing PET detector
  E. Yoshida, G. Akamatsu, H. Tashima, K. Kamada, A. Yoshikawa, T. Yamaya,
  Physics in Medicine & Biology. 66 (2021) 065013

• A digital phoswich detector using time-over-threshold for depth of interaction in PET
  D.L. Prout, Z. Gu, M. Shustef, A.F. Chatziioannou,
  Physics in Medicine & Biology. 65 (2020) 245017

• Investigation of the Power Consumption of the PETsys TOFPET2 ASIC
  V. Nadig, B. Weissler, H. Radermacher, V. Schulz, D. Schug,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 4 (2020) 378–388

• High-Resolution Depth-Encoding PET Detector Module with Prismatoid Light-Guide Array
  A. LaBella, X. Cao, E. Petersen, R. Lubinsky, A. Biegon, W. Zhao, A.H. Goldan,
  Journal of Nuclear Medicine. 61 (2020) 1528–1533

• Development and initial characterization of a high-resolution PET detector module with DOI
  M. Li, Y. Wang, S. Abbaszadeh,
  Biomedical Physics & Engineering Express. 6 (2020) 065020

• Compton PET: a layered structure PET detector with high performance
  P. Peng, M.S. Judenhofer, S.R. Cherry,
  Physics in Medicine & Biology. 64 (2019) 10LT01

• Design Study of a Dedicated Head and Neck Cancer PET System
  M. Li, B. Yockey, S. Abbaszadeh,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 4 (2020) 489–497

• Convolutional Neural Network for Crystal Identification and Gamma Ray Localization in PET
  A. LaBella, P. Vaska, W. Zhao, A.H. Goldan,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 4 (2020) 461–469

• First i-TED demonstrator: A Compton imager with Dynamic Electronic Collimation
  V. Babiano, J. Balibrea, L. Caballero, D. Calvo, I. Ladarescu, J. Lerendegui, S. Mira Prats, C. Domingo-Pardo,
  Nuclear Instruments and Methods in Physics Research A. 953 (2020) 163228

• Exploring TOF capabilities of PET detector blocks based on large monolithic T crystals and analog SiPMs
  E. Lamprou, A.J. Gonzalez, F. Sanchez, J.M. Benlloch,
  Physica Medica. 70 (2020) 10–18

• In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC
  E. Lamprou, F. Sanchez, J.M. Benlloch, A.J. Gonzalez,
  Nuclear Instruments and Methods in Physics Research Section A. 977 (2020) 164295

• Prism Mirror Light Guide for Enhanced Gamma Ray Localization in PET
  A. LaBella, R. Lubinsky, W. Zhao, A.H. Goldan,
  2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2019: pp. 1–4

• Depth-of-interaction study of a dual-readout detector based on TOFPET2 application-specific integrated circuit
  M. Li, S. Abbaszadeh,
  Physics in Medicine and Biology. 64 (2019) 175008

• Performance Characterization of MPPC Modules for TOF-PET Applications
  A.L. Goertzen, D. Van Elburg,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 3 (2019) 475–482

• Initial Measurements with the PETsys TOFPET2 ASIC Evaluation Kit and a Characterization of the ASIC TDC
  D. Schug, V. Nadig, B. Weissler, P. Gebhardt, V. Schulz,
  IEEE Transactions on Radiation and Plasma Medical Sciences. 3 (2019) 444–453

• Operation of microchannel plate PMTs with TOFPET multichannel timing electronics
  S.A. Leach, J.S. Lapington, J.S. Milnes, T. Conneely, R. Bugalho, S. Tavernier,
  Nuclear Instruments and Methods in Physics Research A. 936 (2019) 337–333

• PET detector block with accurate 4D capabilities
  E. Lamprou, A. Aguilar, A. González-Montoro, J.M. Monzó, G. Cañizares, S. Iranzo, L.F. Vidal, L. Hernández, P. Conde, S. Sánchez, F. Sánchez, A.J. González, J.M. Benlloch,
  Nuclear Instruments and Methods in Physics Research A. 912 (2018) 132–136